2,243 research outputs found

    Social-aware Opportunistic Routing Protocol based on User's Interactions and Interests

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    Nowadays, routing proposals must deal with a panoply of heterogeneous devices, intermittent connectivity, and the users' constant need for communication, even in rather challenging networking scenarios. Thus, we propose a Social-aware Content-based Opportunistic Routing Protocol, SCORP, that considers the users' social interaction and their interests to improve data delivery in urban, dense scenarios. Through simulations, using synthetic mobility and human traces scenarios, we compare the performance of our solution against other two social-aware solutions, dLife and Bubble Rap, and the social-oblivious Spray and Wait, in order to show that the combination of social awareness and content knowledge can be beneficial when disseminating data in challenging networks

    Increasing the Transparency, Accountability and Controllability of multi-domain networks with the UPIN framework

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    Demands for a more trustworthy Internet are constantly increasing, in particular to support emerging critical services such as intelligent urban transport systems and smart energy grids. Such cyber-physical systems require more insight into the properties of network operators (e.g., in terms of the security posture of their equipment) and more control over which network operators transport their data, thus going well beyond the traditional security paradigm which the Internet security community currently focuses on (confidentiality, availability, and integrity). In this work-in-progress paper we propose the UPIN framework, which aims to fulfill these new trust requirements. The framework advances the state-of-the-art by defining components needed to incorporate transparency, accountability, and controllability into the Internet or other types of inter-domain networks. The framework is based on our analysis of a smart grid use case to understand the specific needs of critical service providers and a literature study on existing technologies. We also discuss our ongoing work, and the demands and challenges of implementing and deploying the UPIN framework

    Meiotic behavior of a nonaploid accession endorses x = 6 for Brachiaria humidicola (Poaceae).

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    Brachiaria humidicola (Poaceae), originally from Africa, is an economically important pasture plant in tropical South America. An accession of B. humidicola (H038) collected from the wild African savanna (Mbeya, Tanzania) showed irregular microsporogenesis. This meiotic behavior was consistent with an allopolyploid origin. Multivalent chromosome association at diakinesis gave tri- to octavalents, associated with two nucleoli in some cells. Six non-congregated univalents in metaphase I and anaphase I, along with previous lines of evidence for x = 6 in B. humidicola, confirm H038 as a nonaploid accession, 2n = 9x = 54. Asynchrony in the genome during microsporogenesis also corroborated this assumption. Its putative origin could be a cross between two related species with different rhythms in meiosis. The meiotic behavior of this accession reinforces the hypothesis of the existence of a new basic chromosome number (x = 6) for Brachiaria. The use of this accession in the breeding of this important forage grass for the tropics is discussed

    The FisherMan project: Capacity building for sustainable Fisheries Management in the Southwest Indian Ocean

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    The FisherMan project Capacity building for sustainable Fisheries Management in the Southwest Indian Ocean (SWIO) is co-financed by the European Commission through the ACP Edulink programme. FisherMan aims at supporting higher education institutions in the SWIO region to create new study programmes in sustainable fisheries management. This paper presents an overview of the project activities and describes the 1st edition of the FisherMan Regional Conference celebrated during September 2015 in Madagascar whose main aim was to bring together regional and international fisheries experts, authorities, professionals, academics, policy makers and other involved and interested in the Fishery sector, to exchange ideas and to promote an effective collaboration in the South-Western Indian Ocean and increase fishery management education at higher education level.Le projet FisherMan - Renforcement des capacitĂ©s pour la gestion durable des pĂȘcheries dans l’ocĂ©an Indien du sudouest (SWIO) - est co-financĂ© par la Commission EuropĂ©enne Ă  travers le programme ACP Edulink. FisherMan vise Ă  soutenir les institutions d’éducation supĂ©rieur de la rĂ©gion SWIO dans la crĂ©ation de nouveaux programmes d’étude dans la gestion durable de pĂȘcheries. Ce papier prĂ©sente une vue d’ensemble des activitĂ©s du projet et dĂ©crit la premiĂšre Ă©dition de la ConfĂ©rence RĂ©gionale FisherMan qui a eu lieu en septembre 2015 au Madagascar avec comme but principal de rassembler des experts rĂ©gionaux et internationaux en pĂȘcheries, des autoritĂ©s, professionnels, professeurs, chercheurs, dĂ©cideurs politiques et autres impliquĂ©s et intĂ©ressĂ©s par le secteur de la pĂȘche, pour Ă©changer des idĂ©es et promouvoir une collaboration efficace dans l’ocĂ©an Indien su sud-ouest et augmenter l’éducation en gestion de pĂȘcheries au niveau de l’éducation supĂ©rieur.FISHERMAN is a project within the EDULINK Programme: ACP-EU Higher Education Cooperation funded by the European Union and implemented by the ACP Secretariat. Special thanks to the Institut Halieutique et des Sciences Marines of the University of Toliara, to the Ministre de l’Enseignement Supérieur et de la Recherche Scientifique and to the Ministre des Ressources Halieutiques et de la Pêche for their support to the 1st FISHERMAN Conference

    Response to erlotinib in a patient with lung adenocarcinoma harbouring the EML4-ALK translocation: A case report.

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    Lung cancer is the leading cause of cancer-associated mortality worldwide, and the mainstay of treatment remains to be personalised therapy. Tyrosine kinase inhibitors of the epidermal growth factor receptor (EGFR-TKIs) have been reported to exert a significant impact in the treatment of non-small cell lung cancer (NSCLC), particularly in patients harbouring mutations in the EGFR gene. The echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase (EML4-ALK) gene translocation has been described in a subset of patients with NSCLC and possesses potent oncogenic activity. This translocation represents one of the most novel molecular targets in the treatment of NSCLC. Patients who harbour the EML4-ALK rearrangement possess lung tumours that lack EGFR or K-ras mutations. The present study reports the case of a patient possessing the EML4-ALK rearrangement that was initially treated with erlotinib and achieved a lasting clinical response. To the best of our knowledge, the current study is the first report of a clinical response to EGFR-TKI in a patient with lung adenocarcinoma harbouring the EML4-ALK fusion gene, but no EGFR mutations. However, as the disease progressed, the ALK gene status of the tumour was investigated, and based upon a positive result, the patient was treated with crizotinib and achieved a complete response. In conclusion, the present study suggests that the EML4-ALK rearrangement is not always associated with resistance to EGFR-TKIs. Further studies are required to clarify the biological features of these tumours and to investigate the mechanisms underlying the primary resistance to EGFR-TKIs when the EML4-ALK rearrangement is present
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